Our survival is inexorably linked to the Kingdom Fungi. Among its many essential roles, fungi contribute to the global recycling of nutrients, the generation of enzymes used in food production, and the production of antimicrobials. Few of the thousands of known fungal species are capable of causing disease, and yet life-threatening infections caused by these pathogens are increasingly prevalent. The ease with which Candida may form biofilms on medical devices contributes to its persistence among nosocomial infections. Pulmonary and systemic infections caused by Aspergillus, Blastomyces, Cryptococcus, and Histoplasma are often misdiagnosed or diagnosed too late to respond effectively to treatment. Resistance to common antifungals is growing. Our fungal pathogenesis faculty seek to alleviate the global burden of fungal infections by understanding and manipulating the dynamic interplay between fungal pathogen and host.