Dr. Lindsay Kalan and graduate student, Mary Hannah Swaney, have been published in the American Society of Microbiology’s Infection and Immunity’s special issue on “Future Leaders in the Field of Host-Microbe Interactions.”
The article is titled, “Living in Your Skin: Microbes, Molecules, and Mechanisms.” The full article can be read on the American Society of Microbiology’s website.
Human skin functions as a physical, chemical, and immune barrier against the external environment while also providing a protective niche for its resident microbiota, known as the skin microbiome. Cooperation between the microbiota, host skin cells, and the immune system is responsible for maintenance of skin health, and a disruption to this delicate balance, such as by pathogen invasion or a breach in the skin barrier, may lead to impaired skin function. In this minireview, we describe the role of the microbiome in microbe, host, and immune interactions under distinct skin states, including homeostasis, tissue repair, and wound infection. Furthermore, we highlight the growing number of diverse microbial metabolites and products that have been identified to mediate these interactions, particularly those involved in host-microbe communication and defensive symbiosis. We also address the contextual pathogenicity exhibited by many skin commensals and provide insight into future directions in the skin microbiome field.”
Source: American Society of Microbiology