Professor of Medical Microbiology & Immunology
Office: (608) 263-6902, Laboratory: 263-6310
4305 Microbial Sciences Building
1986, B.A., University of California at Santa Cruz, Santa Cruz, CA
1996, Ph.D., Stanford University, Stanford, CA
1996-1999, Research Fellow, Harvard Medical School, Boston, MA
Areas of Study
My lab studies human innate T lymphocytes, with a particular focus on a subset called Natural Killer T (NKT) cells. NKT cells are able to affect the functions of many other types of immune cells, and in so doing they can markedly influence the outcome of immune responses. Because of this, and because they are activated by conserved antigens, NKT cells are of interest as a human lymphocyte population that could be harnessed clinically for immunotherapeutic strategies.
What particularly interests us about NKT cells is that they can become activated by self lipids, which means that they can perform functions even when there is no infectious challenge, and they can amplify immune responses without requiring the presence of a specific foreign antigen. One of the central questions my lab is addressing is to understand how this autoreactivity contributes to inflammatory responses and immune regulation. We are investigating these questions at the molecular and cellular levels, and also in the context of larger immunological processes such as graft-vs-host disease that occurs after transplantation of hematopoietic stem cells, and immune responses during Epstein-Barr virus infection.
2005, Pew Scholar in the Biomedical Sciences
2001, The Medical Foundation Charles A. King Trust Fellowship
1996, Burroughs Wellcome Fellow of the Life Sciences Research Foundation