University of Wisconsin–Madison

Lindsay Kalan

Assistant Professor, Medical Microbiology & Immunology

lkalan@wisc.edu

Office: (608) 262-6977, Laboratory: 262-6980

6155 Microbial Sciences Building

Areas of Study

Symbiosis, Bacterial Pathogenesis

Research Overview

Living in us and on us are trillions of microorganisms; bacteria, fungi, and viruses assemble into complex communities to form the microbiome. Across the biogeography of the human body exists distinct microbial signatures differentiating the gut, oral, airway, and skin microbiomes. Our research is focused on the body’s primary environmental barrier: the skin. We are interested in understanding how microbial communities assemble and interact with each other and their host across the different microenvironments of the skin. A healthy skin microbiome is important to maintain tissue homeostasis and educate the immune system. However, microbial imbalances are also associated with skin disorders and chronic cutaneous infection. We use a highly inter-disciplinary approach that combines high-throughput technologies such as deep sequencing and untargeted metabolomics, with bioinformatics, and wet-lab experimental systems, to elucidate how this balance between beneficial and foreign microbes is maintained at the skin surface and in the context of non-healing chronic wounds.

Lab Website

Publications